Multiple Substrate Usage of Coxiella burnetii to Feed a Bipartite Metabolic Network

Multiple Substrate Usage of Coxiella burnetii to Feed a Bipartite Metabolic Network

The human pathogen Coxiella burnetii causes Q-fever and is classified as a category B bio-weapon. Exploiting the development of the axenic growth medium ACCM-2, we have now used 13C-labeling experiments and isotopolog profiling to investigate the highly diverse metabolic network of C. burnetii. To this aim, C. burnetii RSA 439 NMII was cultured in ACCM-2 containing 5 mM of either [U-13C3]serine...

Metabolic Activity in Coxiella Burnetii.

Ormsbee, Richard A. (Rocky Mountain Laboratory, Hamilton, Mont.), and Marius G. Peacock. Metabolic activity in Coxiella burnetii. J. Bacteriol. 88:1205-1210. 1964.-Purified suspensions of Coxiella burnetii were shown to utilize alpha-ketoglutarate, succinate, fumarate, malate, oxaloacetate, pyruvate, glutamate, and serine. The addition of nicotinamide adenine dinucleotide(+) was necessary to el...

Coxiella burnetii

Q fever has been described for the first time in 1935 as an outbreak of fever in workers of a slaughterhouse in Brisbane, Australia (Derrick, 1937). Derrick could not identify the aetiological agent therefore he defined the disease as “query fever”. Afterwards, in 1937, Burnet and Freeman (Burnet & Freeman, 1937) isolated a troublesome intracellular pathogen from mice inoculated with blood or f...

Susceptibility of Coxiella burnetii to chemical disinfectants.

Coxiella burnetii pneumonia.

This report reviews the pulmonary and extrapulmonary manifestation of infections due to Coxiella burnetii. Q fever, a zoonosis, is due to infection with C. burnetii. This spore-forming microorganism is a small gram-negative coccobacillus that is an obligate intracellular parasite. The most common animal reservoirs are goats, cattle, sheep, cats, and occasionally dogs. The organism reaches high ...